Letter by Petretta and Cuocolo Regarding Article, “Four-Variable Risk Model in Men and Women With Heart Failure”
To the Editor:
Chyu et al1 demonstrated that a simple risk model assessing 4 variables (B-type natriuretic peptide, peak oxygen consumption, New York Heart Association classification, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use) is capable to provide prognostic information in both men and women with advanced heart failure. Using derivation and validation cohorts, they derived and validated a sex-neutral risk model composed of these 4 variables. The model had significant risk discrimination in the total cohort (c-index, 0.786), women (c-index, 0.796), and men (c-index, 0.791) and performed better than the Seattle Heart Failure Model and Heart Failure Survival Score.
We think that further information should be given to …