Association of Adiponectin with Left Ventricular Mass in African Americans: The Jackson Heart Study
Background—African Americans (AA) have a higher prevalence of left ventricular hypertrophy than whites. Several population-based studies have reported an inverse association between adiponectin and left ventricular mass (LVM). However, the relationship between adiponectin levels and LVM has yet to be defined in AA. The Jackson Heart Study (JHS) cohort provides an opportunity to test the hypothesis that the inverse association between adiponectin and LVM may be modified by risk factors common among AA.
Methods and Results—The study population included 2,649 AA JHS participants; mean age, 51 ± 12 years, 63% women, 51% obese, 54% with hypertension and 16% with diabetes. Multiple linear and spline regression was used to assess the association adjusting for demographic, clinical and behavioral covariates. Among all the participants, there was a statistically significant but modest inverse association between adiponectin and left ventricular mass index (LVMI). Hypertension and insulin resistance emerged as statistically significant effect modifiers of this relationship. The inverse association present among the normotensive participants was explained by obesity measures such as the body mass index. Among participants with both hypertension and insulin resistance there was a significant direct association between adiponectin and LVMI after multivariable adjustment (β = 1.55, p = 0.04; per one standard deviation increments in the adiponectin log-value).
Conclusions—The association between serum adiponectin and LVM among AA in the JHS cohort was dependent on hypertension and insulin resistance status. Normotensive AA exhibited an inverse adiponectin — LVM association, whereas participants with hypertension and insulin resistance had a direct association.
- Received October 7, 2010.
- Accepted July 21, 2011.
- Copyright © 2011, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited