Table 3.

Changes During the Course of the Study by Functional Improvement Group

No Functional Improvement, N=13Functional Improvement, N=25P for Interaction
ΔP ValueΔP Value
Brachial blood pressure
 Brachial systolic BP, mm Hg−4.6 (−12.3 to 3.0)0.2−8.8 (−14.3 to −3.3)0.0020.40
 Brachial diastolic BP mm Hg−5.0 (−9.2 to −0.7)0.02−6.2 (−9.2 to −3.2)0.0010.60
 Brachial pulse pressure, mm Hg0.3 (−4.9 to 5.5)0.9−2.6 (−6.3 to 1.2)0.180.40
 Heart rate, beats per minute−0.1 (−3.0 to 2.8)0.90.4 (−1.7 to 2.5)0.70.80
Pulse wave analysis
 Central systolic BP, mm Hg−1.6 (−9.6 to 6.4)0.7−11.6 (−17.5 to −5.7)0.0010.048
 Central pulse pressure, mm Hg1.5 (−3.5 to 6.6)0.6−4.9 (−8.6 to −1.2)0.010.04
 Augmentation index, %−2.6 (−6.6 to 1.4)0.2−4.5 (−7.9 to −1.1)0.010.60
 Augmentation pressure, mm Hg0.1 (−2.6 to 2.8)0.9−3.0 (−5.0 to −1.1)0.0030.06
 Tr, ms2.8 (−3.3 to 8.9)0.44.2 (−0.3 to 8.7)0.070.70
 ED, ms−0.02 (−12.2 to 12.1)1.0−3.9 (−12.9 to 5.1)0.40.60
Wave separation analysis
 Forward pressure wave, mm Hg1.2 (−2.0 to 4.4)0.5−2.8 (−5.1 to −0.5)0.020.047
 Reflected pressure wave, mm Hg0.6 (−1.7 to 2.8)0.6−2.5 (−4.2 to −0.9)0.0030.03
 Reflection magnitude, %−0.01 (−0.06 to 0.04)0.7−0.03 (−0.06 to 0.01)0.120.50
 PWV, m/s0.1 (−0.3 to 0.4)0.8−0.4 (−0.6 to −0.1)0.0020.04
Arterial reservoir analysis
 Excess pressure, mm Hg1.1 (−0.6 to 2.8)0.2−0.04 (−1.6 to 1.5)0.90.30
 Reservoir pressure, mm Hg1.4 (−3.0 to 5.9)0.5−5.1 (−8.3 to −1.8)0.0020.02
  • Δ indicates difference between mean on-treatment and baseline value; BP, blood pressure; ED, ejection duration; PWV, pulse wave velocity; and Tr, time to return of the reflected wave.