Table 4.

Subsequent Clinical Outcomes Based on Initial ADHF Occurrence

OutcomeNo ADHF (n=9193)ADHF (n=168)Hazard RatioLower 95% CIHigher 95% CIP Value
N (%)N (%)
Death from any cause, n (%)323 (3.5)44 (26.2)9.56.713.1<0.001
Death from cardiovascular causes, n (%)79 (0.9)26 (15.5)26.816.243.0<0.001
Myocardial infarction (MI), n (%)180 (2.0)38 (22.6)15.79.924.0<0.001
Non-MI acute coronary syndrome, n (%)75 (0.8)7 (4.2)9.93.721.6<0.001
Stroke, n (%)122 (1.3)16 (9.5) 4.01.48.80.003
  • Data are adjusted for treatment arm, sex, baseline age (in years), baseline chronic kidney disease, and baseline cardiovascular disease. ADHF was a time-dependent covariate in these models. ADHF indicates acute decompensated heart failure; and CI, confidence interval.