Table 1.

Effects of Pericardial Resection in the Dog

Pericardium IntactPericardium IncisedIncised vs Intact
BaselineSalineDelta 1*BaselineSalineDelta 2*Delta 3
MeanSDMeanSDEst95% CIP ValueMeanSDMeanSDEst95% CIP ValueEst95% CIP Value
Primary outcome measure
 LVEDP, mm Hg11230619(14, 23)<0.0011141857(3, 12)0.002−11(−17, 5)0.001
Secondary outcome measures
 LVEDV, mL438561313(5, 20)0.00544566§922(14, 30)<0.00110(−1, 20)0.077
 RA pressure, mm Hg1131636(3, 8)<0.00110312§32(−0, 5)0.062−3(−7, 0)0.062
 PA systolic pressure, mm Hg25536410(7, 14)<0.0012763285(2, 9)0.003−5(−9, −1)0.029
 PA diastolic pressure, mm Hg1112069(4, 14)0.0011231745(−0, 9)0.055−4(−11, 2)0.18
 Cardiac output, L/min2.00.52.90.70.9(0.2, 1.8)0.0472.50.53.20.80.6(−0.3, 1.5)0.145−0.3(−1.6, 1.0)0.63
 Stroke volume, mL1942889(3, 14)0.00824634910(4, 15)0.0041(−7, 9)0.77
 LVEF (%)511557176(−2, 14)0.12759125511−4(−12, 4)0.30−10(−21, 1)0.077
 Heart rate, beats per minute1058107103(−12, 17)0.70106199612−10(−25, 5)0.158−13(−33, 8)0.20
  • Est indicates estimates; LVEDP, left ventricular end-diastolic pressure; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; PA, pulmonary artery; and RA, right atrium.

  • * Delta 1 and Delta 2 are the model-based estimates of the change observed with the introduction of saline in the intact and incised pericardium conditions, respectively.

  • Delta 3 is the difference in deltas between pericardium intact and pericardium incised.

  • Pvalues of <0.001 for comparison of the 2 saline conditions.

  • § Pvalues of (0.001, 0.01) for comparison of the 2 saline conditions.

  • P values of (0.01, 0.05) for comparison of the 2 saline conditions.

  • P values in the range of (0.01, 0.05) for comparison of the 2 baseline conditions.