Table 2.

Effects of Pericardial Resection in the Pig

Pericardium IntactPericardial IncisedIncised vs Intact
BaselineSalineDelta 1*BaselineSalineDelta 2*Delta 3
MeanSDMeanSDEst95% CIP ValueMeanSDMeanSDEst95% CIP ValueEst95% CIP Value
Primary outcome measure
 LVEDP, mm Hg18531213(8, 17)<0.0012062434(−0, 9)0.058−9(−15, −2)0.014
Secondary outcome measures
 LVEDV, mL35846510(7, 14)<0.00141§957817(13, 20)<0.0016(2, 11)0.016
 RA pressure, mm Hg1231725(3, 6)<0.0011231412(0, 3)0.032−3(−5, −1)0.020
 PA systolic pressure, mm Hg3153848(3, 12)0.0063073455(−0, 9)0.062−3(−10, 4)0.34
 PA diastolic pressure, mm Hg1842638(4, 12)0.0021842012(−2, 6)0.29−6(−11, 0)0.056
 Cardiac output, L/min1.90.52.70.50.9(0.5, 1.2)<0.0012.3§0.73.30.41.0(0.6, 1.4)<0.0010.1(−0.4, 0.6)0.66
 Stroke volume, mL2153149(3, 16)0.01127839612(6, 19)0.0023(−6, 12)0.48
 LVEF (%)6196727(−8, 21)0.3466166883(−12, 17)0.71−4(−25, 17)0.67
 Heart rate, beats per minute8778952(−9, 13)0.68898869−3(−13, 8)0.61−5(−20, 11)0.52
  • Est indicates estimates; LVEDP, left ventricular end-diastolic pressure; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; PA, pulmonary artery; and RA, right atrium.

  • * Delta 1 and Delta 2 are the model-based estimates of the change observed with the introduction of saline in the intact and incised pericardium conditions, respectively.

  • Delta 3 is the difference in deltas between pericardium intact and pericardium incised.

  • Pvalues of (0.001, 0.01) for comparison of the 2 saline conditions.

  • § P values in the range of (0.01, 0.05) for comparison of the 2 baseline conditions.

  • Pvalues of <0.001 for comparison of the 2 saline conditions.

  • P values of (0.01, 0.05) for comparison of the 2 saline conditions.