Table 1.

Clinical, Echocardiographic, and Hemodynamic Characteristics in 162 Patients With Obstructive HCM

General Characteristics
Age, y59.2 (10.5)
Male sex, n (%)79 (49)
BMI, kg/m230.9±6.9
Atrial fibrillation, n (%)36 (22)
Medications at RHC, n (%)
 β-blockers135 (83)
 Calcium-channel blockers49 (30)
 Disopyramide20 (12)
 Diuretics39 (24)
Echocardiographic variables
 Peak LVOT gradient, mm Hg90 [70–110]
 LVEF, %65 [61–70]
 Maximum LV wall thickness, mm19.3±3.9
 LV end-diastolic volume index, mL/m251 [43–59]
 MR moderate or severe, n (%)30 (19)
 Left atrial volume index, mL/m242 [36–52]
 Medial E/e′>15, n (%)108 (72)
 RV diameter, mm37 [33–42]
 RV diameter >42 mm, n (%)36 (22)
 RV fractional area change, %47 [43–51]
 Peak tricuspid annulus S′ velocity*, cm/s12.3 [11.0–14.0]
Hemodynamic variables
 PASP, mm Hg41 [31–46]
 Mean PAP, mm Hg25 [20–31]
 mPAP ≥25 mm Hg, n (%)82 (51)
 mPAP 25–34 mm Hg, n (%)53 (33)
 mPAP 35–44 mm Hg, n (%)17 (11)
 mPAP ≥45 mm Hg, n (%)12 (7)
 Right atrial pressure, mm Hg7 [5–10]
 TPG, mm Hg10 [7–13]
 TPG>12 mm Hg, n (%)45 (28)
 PAWP, mm Hg15 [12–20]
 PAWP >15 mm Hg, n (%)74 (46)
 PVR, WU1.89 [1.31–2.57]
 PVR >3.0 WU, n (%)34 (21)
 CI, L/min per m22.51 [2.17–2.91]
 DPG ≥7 mm Hg, %11 (7%)
  • For continuous data, results are reported as mean±SD. For data not distributed normally, results are reported as median (interquartile range). BMI indicates body mass index; CI, cardiac index; DPG, diastolic pressure gradient; LV, left ventricular; EF, ejection fraction; LVOT, left ventricular outflow tract; MR, mitral regurgitation; mPAP, mean pulmonary artery pressure; PAP, pulmonary artery pressure; PASP, pulmonary artery systolic pressure; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RHC, right heart catheterization; RV, right ventricular; TPG, transpulmonary gradient; and WU, Wood units.

  • * Data were available for 92 of 162 patients (57%).