Table 2.

Clinical and Hemodynamic Characteristics With Respect to mPAP

mPAP <25 mm Hg (n=80)mPAP≥25 mm Hg (n=82)P Value
General characteristics
 Age, y56.9 (9.6)61.4 (10.8)0.006
 Male sex, n (%)42 (52.5)37 (45.1)0.43
 BMI, kg/m228.6±5.333.2±7.5<0.001
 NYHA class III or IV at RHC, n (%)55 (68.8)64 (78.1)0.21
 Atrial fibrillation, n (%)17 (21.3)19 (23.2)0.92
Echocardiography
 Peak LVOT gradient, mm Hg90 [75–105]88 [70–110]0.66
 LVEF, %66 [61–71]64 [60–69]0.14
 Maximum wall thickness, mm18.6±3.820.0±3.90.024
 Moderate or severe MR, n (%)12 (15)18 (22)0.31
 Left atrial volume index, mL/m241 [35–48]45 [38–54]0.017
 Left atrial volume index ≥34 mL/m2, n (%)64 (80)75 (92)0.062
 LV diastolic E/A ratio ≥2, n (%)1 (1.3)9 (11.4)0.023
 LV diastolic medial E/e’>15, n (%)46 (60.5)62 (83.8)0.002
 RV diameter, mm36 [32–42]37 [34–42]0.29
 RV diameter >42 mm, n (%)16 (20)20 (24)0.57
 RV fractional area change, %48 [45–51]46 [42–50]0.023
Cardiopulmonary hemodynamics
 PASP, mm Hg31 [28–34]46 [41–56]<0.001
 mPAP, mm Hg20 [18–22]31 [28–38]<0.001
 Right atrial pressure, mm Hg6 [3- 8]9 [7–13]<0.001
 TPG, mm Hg8 [7–10]13 [9–16]<0.001
 TPG>12 mm Hg, n (%)4 (5)41 (50)<0.001
 PAWP, mm Hg12 [10–14]20 [16–24]<0.001
 PAWP>15 mm Hg, n (%)8 (10.0)66 (80.5)<0.001
 PVR, WU1.59 [1.23–2.13]2.45 [1.66–3.26]<0.001
 CI, L/min per m22.52 [2.21–2.96]2.51 [2.16–2.85]0.55
 DPG ≥7 mm Hg, %0 (0)12 (15)<0.001
  • For continuous data, results are reported as mean±SD. For data not distributed normally, results are reported as median (interquartile range). BMI indicates body mass index; CI, cardiac index; DPG, diastolic pressure gradient; LV, left ventricular; EF, ejection fraction; LVOT, left ventricular outflow tract; mPAP, mean pulmonary artery pressure; MR, mitral regurgitation; NYHA, New York Heart Association; PASP, pulmonary artery systolic pressure; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RHC, right heart catheterization; RV, right ventricle; TPG, transpulmonary gradient; and WU, Wood units.