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Circulation: Heart Failure. 2008;1:81-83
doi: 10.1161/CIRCHEARTFAILURE.108.774323
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Challenges for the Basis of Practice

Challenges for the Basis of Practice in Heart Failure

Lynne Warner Stevenson, MD

From the Advanced Heart Disease Section, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Mass.

Correspondence to Lynne Warner Stevenson, MD, Brigham and Women’s Hospital, Division of Cardiology, 75 Francis St, Boston, MA 02115.


    Abstract
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 
Although evidence from clinical trials has significantly informed the management of patients with heart failure, many patients and many clinical situations encountered on a daily basis do not fit neatly into the narrow definitions of trials. In subsequent issues, Circulation: Heart Failure will feature a new series entitled "Challenges for the Basis of Practice," in which readers may submit challenging cases that call for management considerations and decisions that extend well beyond the evidence. An expert consultant will be invited to comment, and readers can also submit responses to these challenging situations so that numerous viewpoints can be explored.

Key Words: heart failure • trials • heart disease


    Introduction
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 
The science of cardiology has helped propel us into the era of evidence-based medicine. For heart failure, the traditional remedy of digoxin was challenged, with subsequent redefinition of benefits and risks. Rational drug development culminated in many clinical trials of new therapies such as neurohormonal antagonists, for which the scope of benefits far exceeds initial anticipation, and inotropic agents, for which the promise has never been fulfilled. Level I and level II recommendations have become the gold and silver currency of the realm. The call to "Get With The Guidelines" resounds with unprecedented unison from the American Heart Association, the American College of Cardiology, and the Heart Failure Society of America.1,2 Outcomes with heart failure have dramatically improved as these guidelines have been incorporated into effective heart failure management. The disease concept has stretched to encompass the oxymoronic asymptomatic heart failure, because it is during this time that treatment may be most effective to improve long-term survival, as suggested by 12-year follow-up of the Studies Of Left Ventricular Dysfunction (SOLVD) prevention arm,3 in which mortality benefit was not evident during the formal trial.4 Twenty-five years ago, patients with heart failure were usually referred only for research studies or cardiac transplantation, often dying within 2 years without transplantation. Now, cardiac transplantation is epidemiologically trivial in heart failure management, with which many patients survive beyond 10 years with their own hearts.


    Limited Evidence for Practice
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 
The expanded basis of evidence from clinical trials remains limited in application to practice. Although the term practice in relation to medicine has often been invoked as "the repetition of an action in order to become proficient," this is the last of the definitions of practice.5 The first is "the actual application of a plan or method, as opposed to the theories relating to it," derived from the Greek praktikos, meaning "concerned with action," from which also comes the adjective practical. Practical decisions must be made every day in the care of individual patients. What are the gaps between trial-based evidence and practice?

Even for successful trials, the fallacy of the mean renders it unlikely that an individual patient will enjoy the average benefit,6 as has been emphasized by Jay Cohn, the founder of the Heart Failure Society of America. This ambiguity of trial results is amplified when beneficial therapies are stacked. While taking 1 proven drug, the trial population that benefits from a new drug may include patients who would derive benefit from both drugs, but it also may combine responders who benefit from one or the other but not both. There is also no reason to believe that the individual is optimally treated with the target dose in the trial, which demonstrates only that aggregate benefit exceeded aggregate toxicity. These uncertainties apply even for the subjects in the trial. Do trial results encompass the larger populations who would have been excluded for comorbidities, many of which increase with age? The Acute Decompensated Heart Failure National Registry (ADHERE), which with more than 100 000 patients hospitalized with heart failure eclipses all trials together,4 has an average patient age of almost 75 years, even in the group with low ejection fraction heart failure; the mean age of patients in heart failure trials is less than 65 years. Fewer than 25% of hospitalized patients would meet heart failure trial criteria,7 yet hospitalization brings most patients to clinical attention. Even if patients and trial subjects were similar, how would trial participants respond in the usual practice settings outside the reimbursed rigor of research organizations? The community experiences with spironolactone demonstrate how a basis of evidence may be altered in translation to practice.8 The relative priority for implantation of devices may be reexamined in a rural indigent setting where patients were not reimbursed for medications.9 Patients differ from the bases of evidence not only in demographics and practice setting, but also for the changing "natural history" of their disease. Since the landmark trials, earlier treatment with angiotensin-converting enzyme inhibitors, β-blockers, and implantable cardioverter-defibrillators has extended the journey and changed the traveler both before and after progression to symptoms that limit daily life.


    Daily Practice: What to Do?
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 
Despite the inevitable limitations, the trials have established the key elements from which to design the effective regimen for an individual patient. Armed with the guidelines, the refractory questions most commonly remaining on a daily basis are not which drug to try but when and how to try it.10 What is target? What is tolerability? For individual patients, it is often necessary to compare absolute benefits and risks rather than the relative benefits and absolute risks as often advertised. What should be added when first-line therapies are poorly tolerated or ineffective? Will we ever find surrogate end points for heart failure therapies as convenient as blood pressure for hypertension and hemoglobin A1c for diabetes? When does symptomatic relief trump other goals of therapy? Optimal therapy often requires understanding of the nature and timing of activities most important to each individual, and the patient preference for quality versus length of life remaining.11

How should the available data be applied to the individual patient? As emphasized during coronary care unit rounds at the University of California Los Angeles by Jan Tillisch, an early proponent of tailored therapy, any fool can make a good decision with good data. If all the relevant data existed, medical care could be relegated to telephone consultants with algorithms. The challenge is to make a good decision with flawed data, which include unbiased trials with limited relevance and relevant experience with unlimited bias. As a keen observer and a clinical trial pioneer, Jay Cohn urges us not to rely exclusively on left brain activity, which converts guidelines to governance and demands new trials to enlighten each uncertainty. Trials can never be performed quickly and cheaply enough to answer even a fraction of the current questions and those raised by each new trial.6,12 The right brain seeks to extrapolate and integrate pieces of information into whole biological and social organisms. Both the left and right brains need to function in daily practice.

The story of β-blocker use provides examples of translation between trials and practice. Reanalyses of the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) demonstrated when and why uptitration of β-blockers was halted before target doses and how benefit on outcomes was equivalent when titration was limited by bradycardia.12 Crucial to defining realistic expectations outside of trials is the prospective analysis of specific strategies, such as the Cleveland Clinic report demonstrating the 70% success of β-blocker initiation, with only half of those patients reaching recommended target doses when diligently pursued in an unselected heart failure clinic population.13 The benefit of β-blockers in patients who did not meet trial criteria was confirmed in a large prospective registry.14 Rather than introducing another new therapy, the Cardiac Insufficiency Bisoprolol Study (CIBIS) III helpfully addressed the common clinical dilemma of which neurohormonal antagonist to start first.15 Such data reinforce the guidelines by positioning them credibly within actual practice.


    Send the Challenge to Practice
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 
Most questions that we face daily with our patients are unanswered by guidelines or their practical translations. It is the purpose of this new section to identify and address challenges that arise commonly in the practice of heart failure medicine. We invite clinicians whose practice includes heart failure patients to summarize in less than 200 words a difficult clinical situation that requires a decision regarding therapy. As it is anticipated that this situation will have arisen multiple times, the presentation should not describe an individual patient, but rather be as general as possible. A Challenge to Practice article may be submitted together by up to 5 clinicians, who can include physicians and/or nurses and will be cited as authors. After selection and initial publication of the article, an expert consultant will be invited to review the relevant literature and his or her own practical approach to the situation. Readers will be invited to submit brief responses, from which representative views will be published. We hope that this new feature will help to guide those who face the challenges, both scientific and humanistic, of caring for patients with heart failure. Even when a challenge cannot be satisfactorily addressed by current experience, the coalescence of efforts should reassure us that we do not practice alone, but within a dedicated common community. Finally, we hope that this feature of Circulation: Heart Failure will not only identify difficult challenges but also inspire the prospective collection of practical experience from which those challenges can in the future be better answered.


    Acknowledgments
 
Disclosures

None.


    References
 TOP
 Abstract
 Introduction
 Limited Evidence for Practice
 Daily Practice: What to...
 Send the Challenge to...
 References
 

  1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Circulation. 2005; 112: e154–e235.[Free Full Text]
  2. Adams KF, Lindenfeld J, Arnold JMO, Baker DW, Barnard DH, Baughman KL, Boehmer JP, Deedwania P, Dunbar SB, Elkayam U, Gheorghiade M, Howlett JG, Konstam MA, Kronenberg MW, Massie BM, Mehra MR, Miller AB, Moser DK, Patterson JH, Rodeheffer RJ, Sackner-Bernstein J, Silver MA, Starling RC, Stevenson LW, Wagoner LE. Executive summary: HFSA 2006 comprehensive heart failure practice guideline. J Card Failure. 2006; 12: 10–38.[CrossRef][Medline]
  3. Jong P, Yusuf S, Rousseau M, Ahn S, Bangdiwala S. Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study. Lancet. 2003; 361: 1843–1848.[CrossRef][Medline]
  4. Yancy CW, Lopatin M, Stevenson LW, De Marco T, Fonarow GC, for the ADHERE Scientific Advisory Committee and Investigators. Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database. J Am Coll Cardiol. 2006; 47: 76–84.[Abstract/Free Full Text]
  5. Compact Oxford English Dictionary. Oxford, UK: Oxford University Press; 2005.
  6. Cohn JN. The fallacy of the mean. J Card Fail. 2001; 7: 103–104.[CrossRef][Medline]
  7. Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, Krumholz HM. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J. 2003; 146: 250–257.[CrossRef][Medline]
  8. Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, Redelmeier DA. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med. 2004; 351: 543–551.[Abstract/Free Full Text]
  9. Hebert K, Mckinnie J, Horswell R, Arcement L, Stevenson L. Expansion of heart failure device therapy into a rural indigent population in Louisiana: potential economic and health policy implications. J Card Fail. 2006; 12: 689–693.[CrossRef][Medline]
  10. Shah MR, Stevenson LW. Searching for evidence: refractory questions in advanced heart failure. J Card Fail. 2004; 10: 210–218.[CrossRef][Medline]
  11. Lewis EF, Johnson PA, Johnson W, Collins C, Griffin L, Stevenson LW. Preferences for quality of life or survival expressed by patients with heart failure. J Heart Lung Transplant. 2001; 20: 1016–1024.[CrossRef][Medline]
  12. Gottlieb SS, Fisher ML, Kjekshus J, Deedwania P, Gullestad L, Vitovec J, Wikstrand J. Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF). Circulation. 2002; 105: 1182–1188.[Abstract/Free Full Text]
  13. Gupta R, Tang WH, Young JB. Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient heart failure clinic. Am Heart J. 2004; 147: 79–83.[CrossRef][Medline]
  14. Jost A, Rauch B, Hochadel M, Winkler R, Schneider S, Jacobs M, Kilkowski C, Kilkowski A, Lorenz H, Muth K, Zugck C, Remppis A, Haass M, Senges J, for the HELUMA study group. Beta-blocker treatment of chronic systolic heart failure improves prognosis even in patients meeting one or more exclusion criteria of the MERIT-HF study. Eur Heart J. 2005; 26: 2689–2697.[Abstract/Free Full Text]
  15. Willenheimer R, van Veldhuisen DJ, Silke B, Erdmann E, Follath F, Krum H, Ponikowski P, Skene A, van de Ven L, Verkenne P, Lechat P, on behalf of the CIBIS III Investigators. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation. 2005; 112: 2426–2435.[Abstract/Free Full Text]




This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Right arrow Articles by Stevenson, L. W.
PubMed
Right arrow Articles by Stevenson, L. W.
Related Collections
Right arrow Other heart failure